Tuesday, June 19, 2007

Looking for Testosterone Gum? How About More Focus and Energy

CHEWABLE TEST?!

Q:I heard about a product recently that is supposed to be a testosterone in gum form. Is this just rumor or is a test gum in the works?

A:I did a little digging because I had not heard about it and, in fact, there has been a gum-like product developed for hypogonadal men. It’s actually a buccal system (Striant) that contains 30mg testosterone. It starts out as a tablet and when exposed to saliva along the gum-line, softens into a gum substance that can be chewed. It is a promising putty-like product that, in tests with 82 hypogonadal men, showed the ability to maintain serum concentrations of testosterone steadily over a 24 hour period. The buccal method also showed promise as a good system of delivery because drainage from the oral cavity circumvents hepatic first-pass catabolism. As the tablet hydrates (from saliva) testosterone is released and absorbed across the buccal mucosa. The single side effect that could create problems with this delivery method is that the inability to tolerate testosterone concentrations on the gums. Other than this, it shows a lot of promise.

MODAFINIL FOR FOCUS AND ENERGY

Q:Have you heard of the drug Modafinil? What are the side effects and possible doses?

A:I haven’t tried it, but from what I know, it is used for people who have trouble staying awake but do not want jitters or the appetite suppressive effects of a drug that is a stimulant. It is supposed to focus you and keep you alert, but doesn’t present any of the negative side effects of amphetamines, such as increased tolerance and finally, addiction. You are supposed to use between 100 and 200mg per day and divide them up in doses throughout the day. There may be a time-release version coming soon, which would make this one obsolete. I did talk to two bodybuilders who currently use it, and they tell me that they use it when bulking and take it in the morning about 3 hours prior to workouts. They report it allows them to work out much longer and harder. They say it’s particularly beneficial when you are not getting as much sleep at night and need to get up and focus. But if that’s the case, you’ll get tired rapidly after about 3 hours on Modafinil. If you are actually sleep deprived, you may not really get benefit from this drug, but if it’s a simple case of getting drowsy at certain times of the day and you’re eating and sleeping fairly normally, it can be a great partner for gym workouts and anything you need to do throughout the day, without being a hindrance to your sanity or mood.

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